MOL File Extension

The MOL file extension was created by Symyx Technologies and is also known as the MDL Molfile. MOL is classified as a Data Files and You can open and render the contents of this file in a Text Editor. You can open MOL files in Avogadro program.

MDL Molfile File Type

MDL Molfile File Type
Extension .mol
Developer Symyx Technologies
Popularity 5.0 (25 Votes)
Mime Type mime-type/not.available
Default Program Avogadro
Category Data Files
Format Text
Updated 7/1/2025

What is a MOL File Type?

The MDL Molfiles also uses .SDF extension.

Free Online MOL Tools & Apps

Access powerful and secure free online MOL tools to convert, view, edit, merge, split, and compare MOL files — all without installing any software. Our tools support the .MOL (MDL Molfile) file extension and run smoothly in any modern browser.

Select a tool below to explore features and manage your MOL files directly from your device with ease.

MOL Files Common Issues

There are few common issues with the MDL Molfile .MOL File Extensions while opening the .MOL files on Windows and MacOs, we have solution to those issues such as:

Can't Open MOL Files?

  1. You must have supported software programs installed for MDL Molfile on your system such as Avogadro.
  2. Associate default Avogadro Avogadro program for *.mol (MDL Molfile) files.

    Associate MOL Default Program on Windows
    1. Right-click a *.MOL (e.g example.mol) file and click Open With.
    2. In the Open with dialog box, click Avogadro Avogadro program Or click Browse to locate the program (*.exe) that you want.
    3. Select check box for Always use this app to open .mol files.

    Associate MOL Default Program on MacOs
    1. Click *.MOL (e.g example.mol) file and click information -> Open With.
    2. In the programs list, click Avogadro Avogadro program Or other appropriate program that you want.
    3. Confirm Change for all... and Contine.
    4. A message will appear "This change will be applied to all files with .Avogadro extension. By clicking Continue you confirm your selection", click Contine to apply changes.

Related MOL File Extensions

MOL default file extension is .MOL and other similer related extensions are:

All Platform Software Programs for MOL File Extension

List of all softwares that can open the MOL files on each platforms such as Windows, Mac, iOS, Linux, Web and Android, you may click the each software link for more details for other supported formats for each software and the verified direct download links for each software with complete lisensing details.

Microsoft Windows logo image Open MOL File on Windows

Software License Developer
Avogadro image. Avogadro 1 for Windows Open Source Avogadro
IQmol image. IQmol 000 for Windows Free IQmol
Okino Computer Graphics PolyTrans image. Okino Computer Graphics PolyTrans 5 for Windows Commercial Okino Computer Graphics

MacOs logo image - FileProInfo.comOpen MOL File on Mac OS

Software License Developer
Avogadro image. Avogadro 1 for MacOs Open Source Avogadro
IQmol image. IQmol 000 for MacOs Free IQmol

Linux logo image - FileProInfo.comOpen MOL file on Linux

Software License Developer
Avogadro image. Avogadro 1 for Linux Open Source Avogadro
IQmol image. IQmol 000 for Linux Free IQmol

Website logo image - FileProInfo.comOpen MOL file on Web

Software License Developer
Okino Computer Graphics PolyTrans image. Okino Computer Graphics PolyTrans 5 for Web Commercial Okino Computer Graphics

iOS logo image - FileProInfo.comOpen MOL file on iOS

Software License Developer

Android logo image - FileProInfo.comOpen MOL file on Android

Software License Developer

About Licensing

  1. Free Trial This software are often used for an attempt period, like 14 days, before requiring payment. Some trial versions have a reduced feature set.
  2. Free This software is liberal to use. Examples include open-source , freeware software, like free programs supported by advertising.
  3. Free+ This software is liberal to download and use, but contains in-app purchases (IAP) to unlock additional content or functionality.
  4. Paid This software must be purchased so as to use it. it's going to be offered as a perpetual license or ongoing subscription.
  5. Included with OS This software is bundled with an OS , like Windows, macOS, or Android.

MOL file extension icon image.About MOL - MDL Molfile

FileProInfo is to help you understand about the MDL Molfile with *.MOL suffix, and provide the complete detail as how to open, edit, convert, merge, split and compare it with other related software programs, software download links and free online apps and tools.

Our professional team members at FileProInfo have been individually researched and verified the details for MOL. We want to be 100% accurate and publish the information about file formats, tools, apps and software programs that we have tested and validated.

If you would like to suggest any additions or updates to this page for MOL, please let us know.

Updated 7/1/2025